An F.D.A. (USA) approved medicine for impotence – Yohimbine is an alkaloid isolated from the bark of yohimbine tree (Pausinystalia Yohimbine) native to West Africa. Yohimbine is a 3a-15a-20B-17a-hydroxy Yohimbine-16a-carboxylic acid methyl ester. Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine. It is a crystalline odourless powder.

Yohimbine increases libido but its primary action is to increase the blood flow to erectile tissue. It is a selective alpha-2 receptor antagonist. YOHIMBINE IS EFFECTIVE IN BOTH PSYCHOGENIC AND ORGANIC CAUSES OF IMPOTENSE. The maximum effect of Yohimbine takes two to three weeks to manifest itself. The standard dose of Yohimbine Hydrochloride is 12 to 20 mg per day. Higher doses have been reported to be more effective, though with side effects.

ACTION: Yohimbine blocks presynaptic alpha-2 adrenergic receptors. Its action on peripheral blood vessels resembles that of reserpine though weaker and of shorter duration. Its effect on peripheral autonomic nervous system is to increase parasympathetic (cholinergic) and decrease the sympathetic (adrenergic) activity. It is noted that in male sexual performance, erection is linked to cholinergic activity and to alpha-2 adrenergic blockade which may result in increased penile inflow and decreased penile outflow of blood. Yohimbine exerts a stimulating action on the mood in higher doses. It has a mild anti-diuretic action. It exerts no significant influence on cardiac stimulation and other effects mediated by B-adrenergic receptors.

INDICATIONS: Considered as the safest and effective medicine for male sexual disorders, YOHIMBINE HYDROCHLORIDE TABLETS are indicated in male erectile dysfunction of organic or psychogenic origin, lack of or low libido and for stimulation of male sex drive.

SIDE EFFECTS: In high doses, Yohimbine may cause Dizziness, nausea, headache, skin flusing and alteration in blood pressure and heart rate. Dosage should be reduced in accordance with individual patient’s tolerance and raised gradually.

CONTRAINDICATIONS: Renal Disease, psychological imbalance, gastric and duodenal ulcers and sensitivity to Yohimbine – such as antidiuresis, mood modifications, and hallucinations. It is not recommended in geriatrics or in conjunction with mood modifying drugs.

DOSAGE: Initiating with 1 tablet t.i.d. gradually increase to 2 or 3 tablets t.i.d. over three weeks…therapeutic treatment not to exceed ten weeks.